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Multimodal imaging and neuromodulation combines fMRI with EEG, fPET, fNIRS, TES (TACS, TDCS, TMS) and HIFU.īACKGROUND: Neuromodulation by transcranial focused ultrasound (FUS) offers the potential to non-invasively treat specific brain regions, with treatment location verified by magnetic resonance acoustic radiation force imaging (MR-ARFI).OBJECTIVE: To investigate the safety of these methods prior to widespread clinical use, we report histologic findings in two large animal models following FUS neuromodulation and MR-ARFI.METHODS: Two rhesus macaques and thirteen Dorset sheep were studied. These methods develop differential image contrast from hemodynamically driven increases in oxygen content in the vascular bed of activated cortex, using pulse sequences sensitive to the paramagnetic behavior of deoxyhemoglobin or to the blood flow changes. Using spiral techniques, we have developed MRI pulse sequences and processing methods for mapping cortical brain function by imaging the metabolic response to various stimuli, with applications in the basic neurosciences as well as for clinical applications.

Presently my research is directed in part towards exploration of rapid scanning methods using spiral and other non-Cartesian k-space trajectories.

We collaborate closely with departmental clinicians and with others in the school of medicine, humanities, and the engineering sciences. My research is devoted to the advancement of imaging sciences for applications in diagnostic radiology. Investigating viscoelasticity of human brain using MR Elastography is of interest as an alternative to BOLD contrast for depicting brain activation. Other interests include multimodal imaging using fMRI in conjunction with EEG, fPET, fNIRS, and neuromodulation with tDCS, tACS, TMS and HiFU. These methods develop differential image contrast from hemodynamically driven increases in oxygen content in the vascular bed of activated cortex (Blood Oxygen Level Dependent, or BOLD contrast), using pulse sequences sensitive to the paramagnetic behavior of deoxyhemoglobin or to the blood flow changes. My research is directed in part towards exploration of rapid MRI scanning methods using spiral and other non-Cartesian k-space trajectories for dynamic imaging of function. My research interests encompass the physics and mathematics of imaging with Magnetic Resonance (MR).